Review Article
The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?
Table 1
Summary of studies in murine models supportive of a significant role of iNKT cells in the pathogenesis of AiLD.
| Model | iNKT cells number | iNKT cells cytokine | Liver injury | References |
| Con-A-treated mice | | IFN-γ IL-4 TNF-α | | [11–13] |
| Con-A-treated mice CCL2/MCP-1 neutralized | | IFN-γ IL-4 TNF-α | | [14] |
| Con-A-treated CD1-deficient mice | (- -) | (- -) | | [15] |
| Con-A-treated SOCS1 cKO mice | NS | IFN-γND IL-4 ND | | [16] |
| Con-A-treated SOCS3 cKO mice | NS | IFN-γ IL-4 | | [17] |
| Con-A-treated PKC-θ(-/-) mice | | IFN-γ TNF-α | | [18] |
| Con-A-treated Parp2(-/- )mice | | IFN-γND | | [19] |
| Con-A or CCl(4)- treated mice | | IL-33 (hepatocytes) | | [20] |
| Con-A-treated tpl2(−/−) mice | | IFN-γ IL-4 | | [21] |
| Con-A-treated PGAM5(−/−) mice | | IFN-γ TNF-α | | [22] |
| Ripk3(-/-) mice | | IFN-γ TNF-α | | [23] |
| dnTGF-βRII mice | | IFN-γ | | [24] |
| Xenobiotic-induced C57BL/6 mice and CD4 and CD8 KO mice | | IFN-γ IL-4 | | [25, 26] |
| NOD.c3c4 mice | | NS | | [27] |
|
|
: increased; : decreased. (- -): absent; NS: not specified; ND: not different from WT. |