Clinical Study

A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease

Figure 1

Randomization schedule for one patient receiving 12 pairs (n = 24) of treatment, each consisting of one week of treatment A and one week of treatment B. Abbreviations: A, treatment A (esomeprazole 40 mg AM and 40 mg PM); B, treatment B (esomeprazole 40 mg AM and placebo PM); T, washout time.