A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease

Table 1

The GerdQ questionnaire respondent enters the frequency scores after reflecting his/her symptoms over the previous week [27].

Questions/frequency	0 days	1 day	2-3 days	4–7 days
1. How often did you have a burning feeling behind your breastbone (heartburn)?	0	1	2	3
2. How often did you have stomach contents (liquid or food) moving upwards to your throat or mouth (regurgitation)?	0	1	2	3
3. How often did you have pain in the center of the upper stomach?	3	2	1	0
4. How often did you have nausea?	3	2	1	0
5. How often did you have difficulty getting a good night of sleep because of your heartburn and/or regurgitation?	0	1	2	3
6. How often did you take additional medications for your heartburn and/or regurgitation other than those your physician told you to take (such as Gaviscon, Tums, Rolaids, and Maalox)?	0	1	2	3

Scoring information: GerdQ score was calculated as the sum of these scores, giving a total score ranging from 0 to 18. Those with a score of 8 or more have a high likelihood of having gastroesophageal reflux disease (GERD), and those with less than 8 have low or no likelihood.