A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease
Table 2
GerdQ † score for the subject participating in individually evaluable GERD ‡ single-patient trial.
Week
Treatment
Total symptoms (score)
1. Heartburn (score)
2. Regurgitation (score)
3. Stomach pain (score)
4. Nausea (score)
5. Difficulty sleeping with heartburn/regurgitation
6. Antacid use
1
A
12
2
3
0
1
3
3
2
B
11
2
3
0
1
3
2
3
A
12
0
3
1
2
3
3
4
B
13
2
3
1
3
2
2
5
B
11
2
2
1
3
2
1
6
B
5
0
1
1
3
0
0
7
A
7
2
2
0
2
1
0
8
A
10
0
2
3
3
2
0
9
A
6
0
0
3
3
0
0
10
A
10
0
2
3
3
1
1
11
B
8
1
1
3
3
0
0
12
B
10
0
2
3
3
0
2
13
B
10
0
2
3
3
0
2
14
A
10
0
2
3
3
0
2
15
B
12
0
2
3
3
2
2
16
A
8
0
2
3
3
0
0
17
A
10
0
2
3
3
0
2
18
B
12
0
2
3
3
2
2
19
B
9
0
2
3
3
0
1
20
A
10
0
2
3
3
0
2
21
B
10
0
0
3
3
2
2
22
A
10
0
2
3
3
0
2
23
A
9
0
1
3
3
0
2
24
B
11
0
2
3
3
1
2
A: treatment A (esomeprazole 40 mg AM and 40 mg PM); B: treatment B (esomeprazole 40 mg AM and placebo PM). †GerdQ: gastroesophageal reflux disease questionnaire. ‡GERD: gastroesophageal reflux disease.
