Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection

Table 1

Clinical outcomes of oral steroid method of preventing esophageal stricture after endoscopic resection.

Author, year	Design	Setting	Sample size; (treated/control)	Follow-up	Stricture rate	Mean or median number of EBD	Adverse event
Lizuka, 2018 [25]	Retrospective cohort study	ESD; 100%; SEC	11/11	Gastroscopy: 1, 4, 8, 12, 16, and 20 weeks after ESD	36.4%VS 82%; (P=0.04)	6.2 VS 19.4; (P=0.023)	8 VS 3; (P=0.043)
Zhou, 2017 [26]	Retrospective cohort study	ESD; >75%; ESCC	13/10	Gastroscopy: 1, 3, 6, and 12 months after ESD	23.1%VS 80%; (P=0.007)	0.69 VS 13.5; (P=0.004)	None
Jean-Philippe,2017 [27]	Single-center retrospective study	EMR; >50%; Barrett’s esophagus	29/0	Gastroscopy: 2, 6, 12, and 24 months after EMR	13%	2	None
Mikinori, 2015[23]	Retrospective cohort study	ESD; >75%; ESCC	17/16	Gastroscopy: 8 weeks after ESD	17. 6%VS; 68.7%; P<0.01	4.6 VS 8.1; P<0.01	None
Hiroki, 2013 [24]	Retrospective cohort study	ESD; 100%; SEC	10/13	Gastroscopy: 7 days, 2-, 3-, and 4-week interval until week after negative endoscopy	Both 100%	13.8 VS 33.5; P<0.001	None
Naoyuki, 2011 [28]	Case report	ESD; 100%; ESCC	1/0	Gastroscopy: 1, 3, and 6 months after ESD	0%	0	None
Hajime, 2011 [29]	Retrospective study	ESD; 100%; ESCC	4/3	Gastroscopy: 3, 6, and 12 months after ESD and then annually thereafter	Both 100%	3.25 VS 32.67; (P<0.05)	None
Naoyuki, 2011 [22]	Retrospective study	ESD; >75%; ESCC	19/22	Gastroscopy: 1, 3, 6, and 12 months after ESD and then annually thereafter	5.3%VS31.8%; (P=0. 03)	1.7 VS 15.6; (P<0. 0001)	None

SEC, superficial esophageal cancer; ESCC, esophageal squamous cell carcinomas.