Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients

Figure 6

Chronological changes of the liver function tests and a summary of treatments in Case 4 (a). Microscopic images of HE staining, MT staining, and immunostaining from the liver biopsy (b, c). HE staining: (A) low-power field, (B) central vein area, and (C) portal area; MT staining: (D) low-power field. The portal area is mainly damaged with mild infiltration of lymphocytes. Infiltration of lymphocytes is also seen in the bile ducts. CD3, upper left panel; CD20, upper right panel; CD8, lower left panel. The number of CD3 or CD8 positive lymphocytes is markedly higher than CD20 positive lymphocytes. ALT, alanine aminotransferase; ALP, alkaline phosphatase; UDCA, ursodeoxycholic acid; Bx, biopsy; PSL, prednisolone; mPSL, methylprednisolone; HYD, hydrocortisone; ACTH, adrenocorticotropic hormone; HE, hematoxylin and eosin; MT, Masson trichrome; CD, cluster of differentiation.

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