Review Article

Dermatological Disorders following Liver Transplantation: An Update

Table 2

Dermatological complications due to immunosuppressant drugs.

ImmunosuppressantDermatological complications

PrednisoloneAcne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper or hypo-pigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.

Mycophenolate mofetilAcne, edema of the face and extremities, erosive stomatitis, immune thrombocytopenia, flushed, dry skin, mofetil hypersudation, sweating.

TacrolimusGingival hyperplasia, immune thrombocytopenia

AzathioprineAcne, bleeding gums, angioedema, isolated localized exanthem, erosive stomatitis, skin rashes, alopecia, acute febrile neutrophilic dermatosis.

CyclosporineAnaphylactic reactions, edema of the face and extremities, epidermal cysts, folliculitis, gingival hyperplasia, hypertrichosis, onychopathy, sebaceous hyperplasia, urticaria.

SirolimusExfoliative dermatitis, angioedema, rash, acne, impairment of wound, healing, hypersensitivity vasculitis, burning eyes, dry eyes, excessive tearing, itchy eyes, capillary leak syndrome, immune thrombocytopenia, stomatitis.

EverolimusPeripheral edema, redness, warmth, swelling, oozing, or slow healing of a wound or surgical incision, easy bruising, cold hands and feet.

CyclophosphamideTemporary alopecia, delayed wound healing, changes in skin color, severe skin reaction (swelling of face or tongue, burning of eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling), changes in nails.

Muromonab-CD3Anaphylactic Reactions- angioedema (including laryngeal, pharyngeal, or facial edema), rash, urticaria, and pruritus.

Rituximab (used in ABO-incompatible liver transplantation)Urticaria, itch, rash, stomatitis, alopecia, flushing, dry skin, pale skin, bleeding gums, pinpoint red spots on the skin, and sweating.