Review Article

Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: A Bidirectional Relationship

Table 1

Studies which assessed T2DM incidence among patients with NAFLD.

Ref.Study design and period of surveillanceNAFLD assessmentCases with T2DM; % in NAFLD vs. non-NAFLD

Shibata et al. 2007 [33]Retrospective cohort study; n = 3,189 (33.6% with NAFLD); male Japanese; 4 yearsLiver ultrasonographyn = 109 incident cases; 1.8% vs. 8.1%
Kim et al. 2008 [34]Retrospective cohort study; n = 5,372 (33.3% with NAFLD); South Korean subjects without diabetes; 5 yearsLiver ultrasonographyn = 234 incident cases; 2.3% vs. 8.5%
Bae et al. 2011 [35]Retrospective study; n = 7,849 (29.2% with NAFLD); subjects without diabetes; 5 yearsLiver ultrasonographyn = 435 incident cases; 3.7% vs. 9.9%
Sung et al. 2012 [36]Retrospective cohort study; n = 12,853 (27.6% with NAFLD); subjects without diabetes; 5 yearsLiver ultrasonographyn = 223 incident cases; 0.8% vs. 4.3%
Kasturirante et al. 2013 [37]Retrospective cohort study; n = 2,276 (40.7% with NAFLD); individuals without diabetes; 3 yearsLiver ultrasonographyn = 242 incident cases; 10.5% vs. 19.7%
Park et al. 2013 [38]Prospective cohort study; n = 25,232 (35% with NAFLD); men without diabetes; 5 yearsLiver ultrasonographyn = 2,108 incident cases; 7% in no steatosis group vs. 17.8% in moderate to severe steatosis group
Zelber-sagi et al. 2013 [39]Prospective cohort study, n = 213; without known liver disease and alcohol abuse; 7 yearsLiver ultrasonographyn = 106 incident cases with NAFLD
Chen et al. 2016 [40]Prospective cohort study; n = 6,542; Chinese subjects without diabetes; 6 yearsLiver ultrasonographyn = 368 incident cases
Li et al. 2017 [41]Prospective cohort study; n = 18,111 (31.8% with NAFLD); Chinese subjects without diabetes without known chronic liver diseases; 4.6 years follow-upLiver ultrasonographyn = 1,262 incident cases; 4.6% in non-NAFLD group vs. 18.1 in moderate to severe NAFLD group
Ma et al. 2017 [42]Retrospective cohort study; n = 1,051 (17.8% with NAFLD); US individuals without diabetes without known chronic liver diseases; 6.2 yearsLiver tomography and ultrasonographyn = 64 incident cases
Liu et al. 2017 [43]Retrospective study, n = 18,507; men without diabetes; 5 yearsLiver ultrasonographyn = 453 incident cases

NAFLD, nonalcoholic fatty liver disease; T2DM, type 2 diabetes mellitus.