Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples

Table 3

Detection sensitivity and specificity of IHC for an EPIYA-C or EPIYA-D motif of H. pylori in gastric biopsy samples compared with the PCR results.

Detection status of each motif By IHC	Number of samples with the PCR results		value	Sensitivity (%)	Specificity (%)
	PCR (+)	PCR (−)
EPIYA-C motif
IHC (+)	26	1	<0.001	84	97
IHC (−)	5	37
EPIYA-D motif
IHC (+)	28	2	<0.001	97	95
IHC (−)	1	38

Detection by IHC or PCR was positive (+) or negative (−) for EPIYA-C or EPIYA-D motif. IHC: immunohistochemistry, Fisher’s Exact Test.