Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Table 2

Allopregnanolone levels (ng/ml) by, group, gender, and age.

Group	Gender	Number	Age	Allopregnanolone (ng/ml)	Significance+
Healthy	Male	4 (10%)	60 (20)	0.042 (0.088)
	Female	35 (90%)	60 (15)	0.030 (0.023)
	Both	39	60 (15)	0.030 (0.025)	r (39) = −0.21
PBC	Male	7 (5.8%)	59 (18)	0.025 (0.045)
	Female	113 (94.2%)	59 (13)	0.032 (0.042)
	Both	120	59 (13)	0.031 (0.042)	r (120) = −0.53

median [IQR]; +analysis using Spearman’s rho; bold denotes statistical significance.