Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Table 3

Age (years) and allopregnanolone (ng/ml) by PBC-40 domain.

PBC-40 domain	Severity	Age (years)	Significance+	Allopregnanolone level (ng/ml)	Significance+
Cognition	None/mild	60 (13)	u = 423	0.024 (0.036)	u = 1034
	Severe	50.5 (12)		0.042 (0.044)
Emotional	None/mild	64 (11)	u = 536	0.024 (0.038)	u = 1374
	Severe	57 (12)		0.039 (0.056)
Itch	None/mild	59 (13)	u = 315	0.030 (0.039)	u = 795
	Severe	50.5 (13)		0.050 (0.101)
Fatigue	None/mild	60 (10)	u = 602	0.027 (0.035)	u = 885
	Severe	57.5 (13)		0.035 (0.047)
Social	None/mild	64 (19)	u = 184	0.025 (0.036)	u = 277
	Severe	57 (10)		0.022 (0.031)
General symptoms	None/mild	59 (15)	u = 205	0.029 (0.040)	u = 214
	Severe	57.5 (7)		0.025 (0.084)

Median (IQR); +analysis using Mann–Whitney U; bold denotes statistical significance.