Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Table 5

POISE response, liver blood tests, and cirrhosis by PBC-40 domain severity.

PBC-40 domain	Severity	POISE response (n = 110)			Liver blood tests (n = 110)			Cirrhosis (n = 110)
		Responders (n)	Nonresponders (n)	Significance+	Normal (n)	Abnormal (n)	Significance+	Noncirrhotic (n)	Cirrhotic (n)	Significance+
Cognition	None/mild	43	15	X(1) = 1.11	20	38	x(1) = 0.705	52	6	X(1) = 0.63
	Severe	15	9		6	18		20	4
Emotional	None/mild	35	11	X(1) = 0.89	17	29	x(1) = 0.37	42	4	X(1) = 0.55
	Severe	24	12		11	25		31	5
Itch	None/mild	71	18	X(1) = 8.25	39	50	x(1) = 3.23	83	6	X(1) = 1.43
	Severe	5	7		2	10		10	2
Fatigue	None/mild	25	9	X(1) = 0.13	13	21	x(1) = 0.013	33	1	X(1) = 0.628
	Severe	30	13		17	26		40	3
Social	None/mild	41	13	X(1) = 0.15	19	54	x(1) = 0.10	51	3	X(1) = 5.93
	Severe	7	3		3	7		7	3
General symptoms	None/mild	54	19	X(1) = 1.59	30	43	x(1) = 1.39	67	6	X(1) = 3.84
	Severe	3	3		1	5		4	2

POISE criteria: ALP ≤ 1.67 × upper limit normal (ULN) and/or bilirubin ≤ 1 × ULN; +analysis using Chi-square; bold denotes statistical significance.