Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy

Figure 1

SARS-CoV-2 function in liver disorder. The SARS-CoV-2 virus can either bind directly to its receptors on the surface of liver cells, such as ACE2 and TMPRSS2, or it can be indirectly through the effect of antiviral drugs or transmitted through the gastrointestinal tract and exert its influence. Besides, increased intrinsic immune system activity such as macrophage cells and the production of proinflammatory cytokines and infection-induced lymphopenia exacerbates clinical symptoms and liver disorders.