Virological Changes of Chronic Hepatitis B Patients with Minimally Elevated Levels of Alanine Aminotransferase: A Meta-Analysis and Systematic Review

Figure 4

The outcomes of HBeAg loss. (a) Pooled risk ratio for HBeAg loss between the antiviral therapy group and control group. (b) Subgroup analysis stratified by therapeutic regimen with or without IFN. (c) Subgroup analysis stratified by monotherapy and combined therapy (IFN plus NAs). (d) Subgroup analysis stratified by therapy duration with threshold of 96 weeks. NAs, nucleos(t)ide analogs; IFN, interferon; CI, confidence interval; monotherapy group exclusively included NAs or IFN. The size of square represents the weight of each study, and the vertical dotted line represents the pooled rate.

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