A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker

Figure 1

Alpha-2-macroglobulin-like 1 (A2ML1) expression was downregulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with poor patient prognosis. (a) A2ML1 mRNA levels were compared between esophageal carcinoma and normal esophageal tissues using The Cancer Genome Atlas and Genotype-Tissue Expression databases; , Student’s t-test. (b) High A2ML1 protein expression in normal tissues was determined using immunohistochemistry (IHC) analysis. (c) Low A2ML1 protein expression in ESCC tissues was determined using IHC analysis. (d) A2ML1 protein levels in 94 ESCC and normal tissues were analyzed; , Student’s t-test. (e) Statistical analysis of the association between A2ML1 expression and survival probability in patients with ESCC; , KMPLOT survival analysis.

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