A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker

Table 2

Cox proportional hazard regression analyses for overall survival.

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age
<60 years
≥60 years	1.045 (0.591–1.848)	0.8808
Sex
Female
Male	0.848 (0.512–1.404)	0.5217
T stage
T1-2
T3-4	1.984 (1.222–3.221)	0.0056	1.376 (0.819–2.312)	0.2285
N stage
N0
N+	1.42 (0.888–2.271)	0.1434	1.377 (0.836–2.27)	0.209
Differentiation
Well
Moderate-poor	1.377 (0.837–2.264)	0.2076	1.349 (0.795–2.288)	0.2669
A2ML1 protein level
Low
High	0.232 (0.137–0.392)	<0.0001	0.252 (0.146–0.436)	<0.0001

; ; A2ML1, α2-macroglobulin-like 1; CI, confidence interval; HR, hazard ratio.