The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study

Table 2

Pleiotropy and heterogeneity test of the UC/CD IVs from nonmalignant digestive system diseases GWAS.

		Pleiotropy test			Heterogeneity test
		MR-egger			MR-egger		IVW
		Intercept	SE	Pval	Q	Q_Pval	Q	Q_Pval
UC	AP	−6.28E − 05	0.009	0.99	58.04	0.82	58.04	0.85
	IBS	9.82E − 05	0.008	0.99	60.97	0.74	60.97	0.77
	GERD	0.001	0.003	0.70	39.30	0.12	39.50	0.14
	Cholelithiasis	0.010	0.005	0.05	99.76	0.009	105.40	0.004
	CeD	0.032	0.038	0.41	177.60	2.57E − 26	183.27	6.06E − 27
	IL-6	−0.007	0.006	0.23	92.81	0.04	94.71	0.04
	CRP	−0.004	0.005	0.47	162.55	2.10E − 19	165.24	1.61E − 19
	TNF-α	0.009	0.008	0.28	64.56	0.63	65.72	0.62
CD	AP	−0.007	0.009	0.44	95.59	0.43	96.21	0.45
	IBS	0.011	0.007	0.15	95.45	0.44	97.63	0.41
	GERD	−1.70E − 04	0.004	0.97	103.61	1.76E − 09	103.61	3.22E − 09
	Cholelithiasis	3.60E − 04	0.006	0.95	215.61	1.51E − 11	215.62	2.30E − 11
	CeD	0.026	0.025	0.29	125.16	6.16E − 15	130.66	1.49E − 15
	IL-6	−0.002	0.004	0.63	84.37	0.32	84.61	0.34
	CRP	0.004	0.003	0.55	50.76	0.0005	51.62	0.0006
	TNF-α	−0.003	0.011	0.76	105.64	0.017	105.77	0.02

IVW, inverse variance weighting; UC, ulcerative colitis; AP, acute pancreatitis; IBS, irritable bowel syndrome; GERD, gastroesophageal reflux disease; IL-6, interleukin 6; CRP, C-reactive protein; TNF-α, tumor necrosis factor-α; CD, Crohn’s disease; GWAS, genome-wide significant; CeD, celiac disease.