The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study

Table 3

MVMR analysis of the effect of ulcerative colitis on acute pancreatitis and irritable bowel syndrome.

Outcome	OR	95% CI	value	Mediation effect (%)
Acute pancreatitis
IVW, crude	1.08	1.03–1.13	0.002
Adjusted for IL-6	1.07	1.02–1.11	0.002	9.44
Irritable bowel syndrome
IVW, crude	1.07	1.03–1.11	<0.001
Adjusted for IL-6	1.07	1.02–1.10	<0.001	0.55

OR, odds ratio; IVW, inverse variance weighting; IL-6, interleukin 6.