Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

Figure 3

The effects of preexisting Hib immune responses on the production of antibodies using a bivalent combined Hib-CP/Hia-CP vaccine. An initial 4 × 10⁴ amount of antigen was used for simulations (a) in the naïve condition (preexisting Ab = 0 and M = 0), (b) in the presence of preexisting anti-Hib antibodies only (preexisting = 10⁶), (c) in the presence of preexisting Hib-specific memory B cells only ( = 400), and (d) in the presence of both anti-Hib antibodies and Hib-specific memory B cells (Ab = 4 × 10⁴ and = 200).

(a)

(b)

(c)

(d)