Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

Figure 4

The effects of preexisting CP and Hib immune responses on the production of antibodies using a bivalent combined Hib-CP/Hia-CP vaccine. An initial 4 × 10⁴ amount of antigen was used for simulations (a) in the presence of preexisting CP-specific and Hib-specific memory B cells only ( = 400 and = 400) and (b) in the presence of preexisting anti-Hib and CP antibodies only (Ab = 10⁶ and = 10⁶).

(a)

(b)