Research Article
Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”
Table 1
Description of model parameters and their values.
| | Parameter | Description | Value | References |
| | Stimulation rate of naïve B cells | 0.5 (antigen) −1 h−1 | [24] | | Activation rate of B cells | 5.88 × 10−2 (MHC II)−1 h−1 | [25] | | Stimulation rate of memory B cells | 1 (antigen) −1 h−1 | Estimated | | Activation rate of memory B cells | 1 (MHC II)−1 h−1 | Estimated | | Rate of MHC II antigen presentation | 6 h−1 | [23] | | Binding rate of antibody with antigen | 60 (antigen molecule) −1 h−1 | [28] | | Death rate of naïve B cells | 4.16 × 10−3 h−1 | [31] | | Death rate of memory B cells | 2.1 × 10−4 h−1 | Estimated | | Activation-induced cell death rate in the absence of antigen | 6.67 × 10−2 h−1 | [31] | | Death rate of plasma B cells | 8.33 × 10−3 h−1 | [29–31] | | Antibody removal rate | 8.33 × 10−3 h−1 | [31] | | Antigen removal rate | 8.33 × 10−3 h−1 | Estimated | | Production rate of naïve B cells from bone marrow | 10 day−1 | [41] | | Rate of antibody production from plasma B cells | 7.2 × 106 (cell)−1 h−1 | [27] |
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