Clinical and Mortality Risk Factors in Bloodstream Infections with Carbapenem-Resistant Enterobacteriaceae

Table 1

Univariate analysis of the clinical characteristics of bloodstream infections caused by CRE and non-CRE.

Clinical characteristics	Bloodstream infections with Enterobacteriaceae, n (%)		value
	CRE group (n = 26)	Non-CRE group (n = 122)
Gender (male)	16 (61.5)	59 (48.4)	0.222
Age > 60 years	22 (84.6)	83 (68.0)	0.091
Community acquired	0	30 (24.6)	0.005
Admission to the ICU	20 (76.9)	10 (8.2)	<0.001
Long-term bedbound	19 (73.1)	61 (50)	0.032
Medical institution admission history within 3 months	17 (65.4)	75 (61.5)	0.709
Underlying diseases
Cardiovascular disease	19 (73.1)	54 (44.3)	0.008
Cerebrovascular disease	21 (80.8)	57 (46.7)	0.002
Chronic respiratory disease	6 (23.1)	9 (7.4)	0.040
Chronic kidney disease	13 (50.0)	33 (27.0)	0.022
Diabetes mellitus	9 (34.6)	44 (36.1)	0.889
Malignant tumor	4 (15.4)	44 (36.1)	0.041
Anemia	26 (100.0)	87 (71.3)	0.002
Hypoalbuminemia	26 (100.0)	98 (80.3)	0.029
Lung infection	22 (84.6)	61 (50.0)	0.001
Urinary tract infection	12 (46.2)	62 (50.8)	0.666
Abdominal infection	5 (19.2)	14 (11.5)	0.453
Tracheotomy	12 (46.2)	21 (17.2)	0.001
Liver dysfunction	13 (50.0)	24 (19.7)	0.001
Invasive surgery before infection
Mechanical ventilation	18 (69.2)	12 (9.8)	<0.001
Central venous catheterization	19 (73.1)	28 (23.0)	<0.001
Indwelling urethral catheterization	25 (96.2)	45 (36.9)	<0.001
Sources of bloodstream infection
Catheter related	10 (38.5)	23 (18.9)	0.029
Respiratory system	11 (42.3)	26 (21.3)	0.025
Urinary tract infection	0 (0)	42 (34.4)	<0.001
Others	5 (19.2)	31 (25.4)	0.505
Prior use of broad-spectrum antibiotics within 30 days	25 (96.2)	39 (32.0)	<0.001
Combined fungal infection	10 (38.5)	10 (8.2)	<0.001
Prior use of glucocorticoids within 30 days	8 (30.8)	11 (9.0)	0.007
Total length of hospital stay	25.4 ± 11.1	21.0 ± 12.7	0.102
30-Day mortality rate	17 (65.4)	21 (17.2)	<0.001
48-Hour mortality rate	6 (23.1)	3 (2.5)	<0.001

ICU: intensive care unit; .