Research Article
The Structure of ampG Gene in Pseudomonas aeruginosa and Its Effect on Drug Resistance
Table 4
MIC levels to ampicillin and AmpC β-lactamase activity of the site-directed mutants.
| | Strain | Amino acid variation | β-Lactamase activity | MIC (μg/ml) |
| | PA01ΔampG-pUCP24-ampGPA-I53S | Ile (atc)-Ser (agc) | 69.8 | 32 | | PA01ΔampG-pUCP24-ampGPA-I53T | Ile (atc)-Thr (acc) | 56.7 | 16 | | PA01ΔampG-pUCP24-ampGPA-W90R | Try (tgg)-Arg (cgg) | 25296.4 | 512 | | PA01ΔampG-pUCP24-ampGPA-WA90S | Try (tgg)-Ser (tcg) | 12628.9 | 512 | | PA01 | / | 1981.6 | 512 | | PA01ΔampG | / | 44.8 | 32 | | PA01ΔampG-pUCP24-ampGPA | / | 5019.3 | 1024 | | ATCC 25922 | / | 0 | 4 |
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