Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

Table 1

Clinical, laboratory, and pathological characteristics of study population.

Variables	HBeAg-positive (n = 254)	HBeAg-negative (n = 237)	χ^2a /Z^b
Gender (male : female)	163 : 91	145 : 92	0.350^a	0.5540
Age (years), median (IQR)	33 (28–39)	42 (35–49)	9.475^b	<0.0001
Serum ALT (IU/L), median (IQR)	67.5 (40.0–154.0)	35.0 (20.0–93.5)	6.587^b	<0.0001
Serum AST (IU/L), median (IQR)	46.0 (29.0–89.0)	28.0 (19.0–56.3)	6.161^b	<0.0001
Serum GGT (IU/L), median (IQR)	31.0 (18.0–71.0)	26.0 (16.8–55.3)	1.751^b	0.0799
Serum ChE (kU/L), median (IQR)	7.525 (6.493–9.086)	8.378 (6.785–9.669)	3.177^b	0.0015
Blood PLT (×10^9/L), median (IQR)	171 (139–207)	169 (127–208)	1.017^b	0.3091
Serum anti-HBc (log10 IU/L), median (IQR)	3.526 (3.137–3.806)	4.222 (3.668–4.641)	10.747^b	<0.0001
Serum HBsAg (log10 IU/L), median (IQR)	4.010 (3.446–4.596)	3.282 (2.762–3.615)	11.902^b	<0.0001
Serum HBV DNA (log10 IU/L), median (IQR)	7.228 (6.336–7.806)	3.565 (<2.699–5.235)	15.327^b	<0.0001
Intrahepatic HBsAg (0 : 1 : 2 : 3)	3 : 54 : 95 : 102	17 : 104 : 82 : 34	60.061^a	<0.0001
Intrahepatic HBcAg (0 : 1 : 2 : 3)	103 : 70 : 64 : 17	207 : 27 : 3 : 0	126.052^a	<0.0001
Pathological grade (0 : 1 : 2 : 3 : 4)	0 : 153 : 85 : 16 : 0	0 : 182 : 39 : 16 : 0	19.009^a	0.0001
Pathological stage (0 : 1 : 2 : 3 : 4)	0 : 115 : 89 : 16 : 34	0 : 140 : 47 : 16 : 34	14.851^a	0.0019

IQR, interquartile range; ALT, alanine transferase; AST, aspartate transferase; GGT, gamma-glutamyl transpeptidase; ChE, cholinesterase; PLT, platelet; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; HBcAg, hepatitis B core antigen; anti-HBc, antibodies to hepatitis B core antigen; HBV DNA, hepatitis B virus DNA. ^#Comparison between HBeAg-positive and HBeAg-negative patients; ^aPearson chi-square test; ^bMann–Whitney U test.