Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection

Table 2

Differences in Spearman correlation coefficients among serum and intrahepatic HBV markers with pathological grades and stages.

Variable	HBeAg-positive (n = 254)				HBeAg-negative (n = 237)
	Pathological grade		Pathological stage		Pathological grade		Pathological stage
	rs		rs		rs		rs
Serum anti-HBc	0.312^ab	<0.0001	0.268^c	<0.0001	0.270^d	<0.0001	0.147^e	0.0237
Serum HBsAg	−0.248	0.0001	−0.272	<0.0001	0.183	0.0046	0.127	0.0503
Serum HBV DNA	−0.073^a	0.2470	−0.128	0.0410	0.493^d	<0.0001	0.411^e	<0.0001
Intrahepatic HBsAg	0.017^b	0.7825	0.030^c	0.6380	0.212	0.0010	0.221	0.0006
Intrahepatic HBcAg	−0.270	<0.0001	−0.254	<0.0001	0.220	0.0007	0.169	0.0093

^a–ePairwise comparisons between different Spearman correlation coefficients, , by Fisher’s Z test. a: Z = 2.797, ; b: Z = 3.425, ; c: Z = 2.741, ; d: Z = 2.846, ; e: Z = 3.123, .