Research Article
Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug-Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Table 2
Regional analysis for extracellular pH (pHe) imaging before and after infusion of SPIO-NPs for all RG2 tumor-bearing rats that underwent coinfusion of TmDOTP5− and probenecid (). See Figure 3(b) for details. The was measured inside the MRI-defined tumor core (see Figure S2), at the tumor edge (regions 1 mm outside the tumor boundary), and in the healthy/nontumor tissue before and after the infusion of SPIO-NPs. Data shown are mean and standard deviation (SD).
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