Preliminary ¹⁹F-MRS Study of Tumor Cell Proliferation with 3′-deoxy-3′-fluorothymidine and Its Metabolite (FLT-MP)

Figure 5

In vivo MR spectrum in a mouse tumor model. FLT (200 mM, 100 μL) was injected into tail veins. (a) Anatomical ¹H MR images of the mouse were obtained using fast spin echo sequence with the voxel of interest in the tumor (5 × 5 × 5 mm³). Time-course of MR spectra at (b) 25 min after injection (a.i.) ( ppm) and (c) 90 min a.i. ( ppm). ¹⁹F MRS data were acquired with Point-REsolved Spectroscopy (PRESS) using TR 3000 ms, TE 15 ms, averages 512, scan time 25 min.

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(b)

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