Contrast Media & Molecular Imaging

Clinical Study

Comparison of Diagnostic Performance of Three-Dimensional Positron Emission Mammography versus Whole Body Positron Emission Tomography in Breast Cancer

Table 6

Comparison of diagnostic performance of 3D-PEM and WBPET after exclusion of lesions beyond the range of 3D-PEM detector.


Total cases

	WBPET n = 243		3D-PEM n = 243		P value
	+	−	+	−	P value

Histopathology +, n = 200	191	9	194	6
Histopathology −, n = 43	18	25	20	23
Sensitivity (%)	95.5		97.0		0.913
Specificity (%)	58.1		53.5		0.517
Accuracy (%)	88.9		89.3		1.0

	WBPET n = 43		3D-PEM n = 43		P value
	+	−	+	−	P value

Lesion < 1 cm
Histopathology +, n = 25	15	10	18	7
Histopathology −, n = 18	5	13	6	12
Sensitivity (%)	60.0		72.0		0.685
Specificity (%)	72.2		66.7		0.878
Accuracy (%)	65.1		69.8		0.613

	WBPET n = 225		3D-PEM n = 225		P value
	+	−	+	−	P value

Lesion ≥ 1 cm
Histopathology +, n = 195	179	16	183	12
Histopathology −, n = 30	14	16	15	15
Sensitivity (%)	91.8		93.8		0.835
Specificity (%)	53.3		50.0		0.884
Accuracy (%)	86.7		88.0		0.912