Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy

Figure 2

Perfusion monitoring using dynamic contrast-enhanced (DCE) MRI in liver metastasis after anti-VEGF treatment (bevacizumab). DCE-MRI requires the acquisition of (a) time series of signal intensity data converted into (b) a gadolinium contrast agent concentration–time curve and (c) an arterial input function, . (d) Model-fitting enables calculation of bulk transfer coefficient () and a map of extensive liver metastasis overlaid on a slice from -weighted MRI. (e) reduced three days after treatment with bevacizumab. (f) Proportion of decrease in over time (adapted from [13]).

(a)

(b)

(c)

(d)

(e)

(f)