Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy

Figure 6

Multi-slice assessment of extracellular pH (pHe) of the tumor, kidney, and bladder using acidoCEST MRI and exogenous contrast agent, iopromide, in a mice model of MDA-MB-231 human mammary carcinoma. (a) The tumor showed an average pHe of 6.74. (b) The pHe increased from the renal pelvis (6.54) to the cortex (6.84). (c) The bladder had a pHe of 6.3. The region into which the bladder swells after injection during infusion could not be fit, indicating that the fitting method used is robust against overfitting (adapted from [17]).

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(b)

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