Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy

Figure 7

Glioma metabolism using hyperpolarized [2-¹³C]pyruvate before and after dichloroacetate (DCA) administration. 125-mM hyperpolarized [2-¹³C]pyruvate was injected intravenously into a rat with C6 glioma cells. Metabolite maps of (a) [2-¹³C]pyruvate, (b) [2-¹³C]lactate, and (c) [5-¹³C]glutamate from a tumor slice of a representative glioma-implanted rat brain, measured pre- and post-DCA. (d) Contrast-enhanced -weighted ¹H MRI of the corresponding slice (adapted from [18]).