High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26

Figure 4

In vivo binding specificity of ⁵⁷Co-NOTA-PEG₂-RM26 in (a) NMRI mice at 30 min pi and (b) PC-3 xenografted Balb/c nu/nu mice at 3 h pi. The total injected mass of radioconjugate was 45 pmol. All animals in the blocked group were coinjected with 20 nmol of nonlabeled peptide. Data are presented as an average % ID/g and standard deviation for four mice. stands for significant difference () in uptake of radioactivity in the respective organs between the blocked and nonblocked groups of mice.

(a)

(b)