Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging

Figure 5

Representative in vivo fusion images of c-sestamibi and coNGR uptake in MI mice. In “grey” is the uptake of c-sestamibi in myocardium, while uptake of coNGR is in “hot metal” color. In (a) and (b) slices of an infarcted heart are shown. The infarct area is visualized by the decreased uptake of c-sestamibi (in grey) which is clearly visible in the anterolateral region of the heart (arrowheads). Enhanced uptake of coNGR is clearly visible in the infarct area (arrows). Note: the uptake is color coded and relative to the injected dose per animal. SA: short axis; VLA: vertical long axis.

(a)

(b)