Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma

<div>Two pathological images of treated hepatocellular carcinoma at 7 days. (a) Anti-CD31 immunohistochemistry with USPIO particles counterstaining shows blue iron particles within tumor vessels (black arrows) (magnification ×200). (b) Anti-CD68 immunohistochemistry with USPIO particles counterstaining shows several brown stained macrophages (white arrow heads) and blue iron particles within the structures (black arrows) which are consistent with positively stained vessels on anti-CD31 staining (magnification ×200).</div>

Contrast Media & Molecular Imaging

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Figure 4: Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma 

Figure 4 | Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma 