Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy

<div><i>Incorporation of cellular labeling.</i> Human T-cells were expanded to 1 L of culture in a GE Wave 2/10 bioreactor. (a) By adding CS-1000 ATM through a vented spike, a closed sterile system was able to be maintained. Vials containing 27 mL of CS-1000 ATM were fed either by gravity (not shown) or by peristaltic pump through a vented vial spike. With this method of delivery, 25 mL of reagent is delivered per vial. (b) 27 mL vial imaged with the vented spike.</div>

Contrast Media & Molecular Imaging

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Figure 1

Figure 1: Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy 