Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy

<div><i>Phenotypic examination of labeled cells</i>. Labeled and unlabeled T-cell populations are compared for the presence of the following phenotypic markers: CD3, CD4, CD8, and CD32. (a) Histograms comparing cellular populations labeled with conjugated antibodies for the depicted surface marker or isotype control. (b) Table summarizing the cellular populations (n2) presenting <svg height="11.439pt" id="M9" style="vertical-align:-2.15067pt" version="1.1" viewbox="-0.0498162 -9.28833 20.7949 11.439" width="20.7949pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M535 230V280H323V490H265V280H52V230H265V-3H323V230H535Z" id="g117-36"></path></g><g transform="matrix(.013,0,0,-0.013,7.631,0)"><path d="M368 703H309L44 -163H104L368 703Z" id="g113-48"></path></g><g transform="matrix(.013,0,0,-0.013,12.992,0)"><path d="M535 230V280H52V230H535Z" id="g117-33"></path></g></svg> CS-1000 ATM labeling and <svg height="11.439pt" id="M10" style="vertical-align:-2.15067pt" version="1.1" viewbox="-0.0498162 -9.28833 20.7949 11.439" width="20.7949pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M535 230V280H323V490H265V280H52V230H265V-3H323V230H535Z" id="g117-36"></path></g><g transform="matrix(.013,0,0,-0.013,7.631,0)"><path d="M368 703H309L44 -163H104L368 703Z" id="g113-48"></path></g><g transform="matrix(.013,0,0,-0.013,12.992,0)"><path d="M535 230V280H52V230H535Z" id="g117-33"></path></g></svg> cryopreservation.</div>

Contrast Media & Molecular Imaging

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Figure 3

Figure 3: Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy 