Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma

Figure 6

Histological analysis of tumors. (a, b) Histological sections of tumors treated with saline. Morphology of cancer cells is preserved with negligible signs of tissue modifications. (c, d) In tumors treated only with MNs, nanoparticles are clearly marked by Prussian blue staining. No evident signs of cytotoxic effects were detectable. (e, f) Tumors injected with MNs and exposed to AMF showed clusters of MNs surrounded by large areas of tissue necrosis induced by hyperthermic treatment (scale bar, 100 µm and 50 µm for the left and right column, resp.).

(a)

(b)

(c)

(d)

(e)

(f)