Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA

Figure 4

Role of liver temperature on Gd-BOPTA liver concentrations. (a) ¹⁵³Gd-DTPA and ¹⁵³Gd-BOPTA concentrations after a 30 min perfusion (200 µM, 38°C). (b) Time course of contrast agent concentrations in hepatic veins (mean ± SD, n = 3). (c) MR images of tubes containing biopsies of livers perfused during 30 min with Gd-BOPTA (200 µM) at 12, 25, 30, 36, and 38°C. The signal intensity of livers perfused at 38°C is 100%. Data are mean ± SD (n = 3). Adapted from [22] with permission.

(a)

(b)

(c)