Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA

<div>Gd-BOPTA concentrations over time in structures identified at clinical MRI. Values are either liver concentrations assessed by the gamma counter (a) or true concentrations in bile (b). Gd-BOPTA (200 <i>μ</i>M) is perfused from 45 to 75 min and replaced by a rinse solution from 75 to 105 min. Two groups of rats are studied: normal rats (<i>n</i> = 5, black symbols) and rats lacking Mrp2 (n = 3, grey symbols). Adapted from [<a href="/journals/cmmi/2018/3839108/#B14">14</a>] with permission.</div>

Contrast Media & Molecular Imaging

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Figure 6

Figure 6: Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA 