NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye

<div><i>Design and synthesis of </i><svg height="15.5441pt" id="M1" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -11.7101 25.0224 15.5441" width="25.0224pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M501 640C462 634 422 626 376 611C189 552 52 397 52 193C52 74 120 -12 229 -12C347 -12 453 91 453 223C453 324 395 398 297 398C279 398 257 391 237 382L169 350L168 351C221 484 322 548 396 578C437 595 473 605 506 611L501 640ZM253 347C346 347 368 272 368 211C368 104 318 20 242 20C169 20 138 105 138 193C138 251 147 289 156 314C179 329 218 347 253 347Z" id="g189-227"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.523,-5.741)"><path d="M311 635C205 635 120 557 120 465C120 400 161 360 203 327C163 302 116 272 90 250C54 220 36 186 36 141C36 42 119 -12 211 -12C327 -12 431 70 431 176C431 249 383 294 320 341C376 377 400 395 414 406C441 429 457 465 457 499C457 585 385 635 311 635ZM294 603C347 603 382 562 382 500C382 442 351 393 295 358C254 388 195 421 195 493C195 552 235 603 294 603ZM227 20C158 20 118 71 118 143C118 214 165 270 230 308C299 262 347 220 347 153C347 73 296 20 227 20Z" id="g189-152"></path></g><g transform="matrix(.013,0,0,-0.013,9.395,0)"><path d="M673 297H417L411 270C517 261 522 258 506 183L487 92C476 38 428 19 360 19C207 19 123 132 123 287C123 472 243 631 441 631C557 631 617 583 617 469L647 472C650 545 655 604 658 632C625 643 554 666 467 666C201 666 23 502 23 278C23 90 156 -16 339 -16C410 -16 501 6 569 24C566 43 567 70 573 101L589 183C604 259 607 262 667 271L673 297Z" id="g113-72"></path></g><g transform="matrix(.013,0,0,-0.013,18.287,0)"><path d="M483 97L471 123C436 91 401 65 392 65C388 65 384 74 390 106C414 239 444 378 457 429L455 433C444 433 429 436 416 439C392 444 368 448 344 448C281 448 204 415 152 376C71 315 23 205 23 103C23 21 57 -12 85 -12C114 -12 149 6 185 34C231 70 285 119 329 183H331L309 81C292 0 308 -12 326 -12C350 -12 421 24 483 97ZM374 387C370 363 356 291 345 261C315 193 181 50 139 50C124 50 110 71 110 118C110 224 153 331 218 379C238 394 271 402 301 402C329 402 359 394 374 387Z" id="g113-98"></path></g></svg><i>-MHI-148 probe</i>. (a) Chemical structure of MHI-148 compound. (b) Synthesis and radiolabeling of NIRF optical/PET dual-modal probe <sup>68</sup>Ga-MHI-148.</div>

Contrast Media & Molecular Imaging

fig1

Figure 1

Figure 1: NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye 