NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye

Figure 2

Uptake of NIRF dye in HCC PDX models. (a) NIRF imaging of PDX models established by implanting three different fresh human HCC specimens into nude mice subcutaneously. (b) Quantification of NIRF dye uptake in (a) (per cm²). Data are presented as the ratio of dye uptake intensity as normalized to that of blank region (mean ± SD, ). (c) H&E analyses of tumor tissues derived from both PDX mouse models and original patient samples. (d) AFP expression in tumor tissues derived from both PDX mouse models and original patient samples. Representative images are shown. Original magnification, ×400; scale bars represent 20 μm.

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