NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye

Figure 4

PET imaging detection of orthotopic HCC tumors in nude mice. (a) The ⁶⁸Ga-MHI-148/PET conjugate was used to detect HCC orthotopic xenograft models in mice. Strong nuclear signals can be observed at the tumor tissue site (red circle) as compared with that of normal tissue. Representative images are shown. (b) Standardized uptake value (SUV) and tumor volume of live orthotopic tumors in mice according to PET scan after injection with ⁶⁸Ga-MHI-148. (c) Tumor SUV-to-muscle (cancer-adjacent normal muscle tissues) SUV ratios (T/M) are shown.

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