NIRF Optical/PET Dual-Modal Imaging of Hepatocellular Carcinoma Using Heptamethine Carbocyanine Dye

Figure 5

PET imaging detection of orthotopic liver tumors in rabbits. (a) PET/CT scan was performed for liver cancer orthotopic xenograft models in rabbit after the injection of ⁶⁸Ga-MHI-148. Strong signals were detected in the liver region (left), and the histology of the targeted cancerous area was confirmed by H&E staining (right). Unlabeled MHI-148 was injected into the sixth rabbit and exhibited a lack of tumor accumulation at tumor sites. Original magnification, ×200; scale bars represent 20 μm. (b) Standardized uptake value (SUV) and tumor volume of live orthotopic tumors in rabbit by PET scan. (c) Ex vivo NIRF imaging of rabbit liver cancer using small animal optical imaging system. (d) Quantification of NIRF intensity within the tumor area (per cm²) in (c).

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