Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Figure 6

Experimental and fit of [¹¹C]AM7 under control conditions. (a) Scan with available image data for urine and with blood and tissue data from dissection. (b) Scan without control data from dissection and no complete urinary bladder in the images. Circles, image data; squares, data from dissection ((a), at 68 min). Lines, fits of the image data. Colour code, see insert. Dotted green line, simulated fraction of in compartment H₂ (see Figure 2). Dotted red line (+Reabsorbed), sum of the compartments G and the fraction reabsorbed according to (Figure 2). Broken red line (Transintestinal), simulated tracer excretion from plasma to intestines, according to in Figure 2. Note that urinary data in (a) (light blue circles) were not fitted but were predicted from the modelling (light blue line). and BW are indicated in the panels. CD1 nu/nu mice.

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