Brain Network Alterations in Alzheimer’s Disease Identified by Early-Phase PIB-PET

Figure 1

Correlated components of ¹¹C-pPIB and ¹⁸F-FDG. (a) Loading parameters with a significant correlation in all participants with ¹⁸F-FDG (red) and ¹¹C-pPIB (green). (b) Common regions of the correlated ¹⁸F-FDG and ¹¹C-pPIB components, including bilateral medial frontal gyrus, temporal lobe, and right insular lobe. (c) Correlated components of ¹¹C-pPIB (left) and ¹⁸F-FDG (right), including the medial frontal gyrus, anterior cingulate cortex, posterior cingulate cortex/precuneus, superior temporal gyrus, temporal pole, and orbitofrontal gyrus. ¹¹C-pPIB, (¹¹C)-labeled Pittsburgh Compound B; ¹⁸F-FDG, fludeoxyglucose F 18.

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