Brain Network Alterations in Alzheimer’s Disease Identified by Early-Phase PIB-PET

Table 4

¹¹C-pPIB–revealed hypoperfusion brain areas differentiating AD and CN groups.

Brain region	Voxel-level			X	Y	Z
	T	Z
R ITG/BA19	5.66	4.50	0.000	54	−64	−6
	5.32	4.31	0.000	54	−66	14
L STG/BA22	5.00	4.13	0.000	66	−46	6
Limbic lobe/L ParaHippo	4.74	3.97	0.000	−22	4	−22
BA23/PCC	4.41	3.76	0.000	2	−38	24
	4.15	3.59	0.000	−2	−26	30
Insula/BA13	4.39	3.74	0.000	42	−20	12
R STG/BA39	4.37	3.73	0.000	58	−56	26
L STG/BA22	4.18	3.60	0.000	−52	0	0
R ITG/BA20	3.89	3.41	0.000	58	−8	−34
ACC/BA24	3.86	3.38	0.000	2	32	16
Limbic lobe/R ParaHippo	3.84	3.38	0.000	14	−38	−2
R SPL/BA7	3.82	3.35	0.000	36	−58	54
R IPL/BA40	3.81	3.32	0.000	40	−48	44

Threshold: , = 0.001; Extent threshold: voxel, Voxel size:  mm. ¹¹C-pPIB: (¹¹C)-labeled Pittsburgh Compound B; AD: Alzheimer’s disease; CN: cognitively normal; ITG: inferior temporal cortex; STG: superior temporal gyrus; BA: Brodmann area; ACC: anterior cingulate cortex; SPL: superior parietal lobe; IPL: inferior parietal lobule.