Research Article
Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging
Table 1
Summary of characterizations of NPs before and after functionalization with chelating silanes.
| | Properties | Method(s) | SiGdNP | SiGdNP @ D-1 | SiGdNP @ N-1 |
| | DH (nm) | DLS | 4.2 ± 0.8 | 4.5 ± 0.9 | 4.5 ± 0.9 | | Zeta potential (mV) | Zetametry | +8.2 (pH 7.0) | −8.3 (pH 7.0) | −13.7 (pH 7.0) | | Free COOH band | IR | No | Yes | Yes | | Retention time (min) | HPLC (295 nm) | 13.6 | 15.3 | 14.7 | | Free chelator content (µmol/mg) | Eu3+ titration | 0.025 | 0.10 | 0.10 | | Gd content (µmol/mg) | ICP-OES | 0.890 | 0.763 | 0.763 | | r1 (mM−1·s−1) (37°C, 60 MHz) | Relaxometry | 14.33 | 17.97 | 18.17 | | r2/r1 | Relaxometry | 1.36 | 1.42 | 1.42 | | Gd : Si : N : C | Elemental analysis | 1.0 : 4.8 : 6.0 : 25.3 | 1.0 : 6.5 : 7.3 : 30.7 | 1.0 : 6.1 : 7.2 : 30.8 |
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