InVivo Molecular Ultrasound Assessment of Glioblastoma Neovasculature with Endoglin-Targeted Microbubbles

Figure 4

The experiment design of in vivo molecular US imaging experiment. Subcutaneous tumor models were established for the assessment of CD105 expression levels during tumor progression from small to large size. The nontargeted MBs were injected and measured as the control, and the CD105-targeted MBs were injected with a 40 min interval after the injection of nontargeted MBs. The US signals from the CD105-targeted MBs would be calculated by averaging predestruction and postdestruction imaging signals and subtracting the postdestruction signal average from the predestruction signal average.