Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd

Figure 5

(a) Thermal image of mice before and after irradiation for the saline group and (D5) group; (b) sections of the heart, liver, spleen, lung, and kidney of mice stained with H&E after saline and GO-AuNS treatment; (c) bioluminescence images of the HCC-LM3-fLuc tumor-bearing nude mice that received (A) saline through tail vein without laser irradiation, (B) saline through tail vein with laser irradiation, (C) GO-AuNS through tail vein without laser irradiation, (D2) laser irradiation on 2nd h postinjection of GO-AuNS through tail vein, (D5) laser irradiation on 5th h postinjection of GO-AuNS through tail vein, (D12) laser irradiation on 12th h postinjection of GO-AuNS through tail vein, (E) GO-AuNS via intratumor injection without laser irradiation, and (F) laser irradiation on 2nd h postinjection of GO-AuNS via intratumor injection; (d) the quantified bioluminescence intensity of tumors from the eight groups on day 5 posttreatment; (e) the average weight of mice from the eight groups over time ( per group).

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