Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients

Figure 2

Expression of bone markers in prostate cells. (a) Graph shows the number of RUNX2-positive prostate cells in BL, BM+, and BM− lesions. (b) Numerous nuclear RUNX2-positive cancer cells in BM− lesions (scale bar represents 50 µm). (c) Nuclear RUNX″ expression in prostate cancer cells of a BM+ patient (scale bar represents 50 µm). (d) Graph displays the number of RANKL-positive prostate cells in BL, BM−, and BM+ lesions. (e) RANKL expression in a case of BM− patient (scale bar represents 50 µm). (f) Numerous prostate cancer cells expressing RANKL in BM+ (scale bar represents 50 µm). (g) Graph shows the number of nuclear VDR-positive prostate cells in BL, BM−, and BM+ lesions. (h) VDR-positive prostate cancer cells in a BM− lesion (scale bar represents 50 µm). (i) Several nuclear VDR-positive prostate cancer cells in a BM+ lesion (scale bar represents 50 µm).

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